Well obviously, since 1.e4 e5 2.f4 (King's gambit I take?) sacrifices a pawn. Now 1.f4 does not allow black to play e5 without giving up a pawn. (The From, which is playable by the way.)
However, the ''normal'' way to play it is 1.f4 d5 2.Nf3 Nf6 3.d3 (for example) Then white will attempt to press on e4 at some point, setting up the ideal e4/f4 centre, but with backup from the d3 pawn. You can also say it is a Dutch defence upside down. There are many ways to play it, such as the reversed Stonewall, (f4 and d4, not intending e4 at all) the reversed classical, (d3 and e3 and later you play e4) and the reversed Leningrad (d3 and g3 and Bg2, with the idea to play the e2 pawn to e4 in one go)
There's no easy way to answer your question, if you want to talk about a specific variation, feel free.
How to play Bird System (1.f4)? Is there any tip? Is the concept differ from KG?