For serious play, 1.d4 (of course that means a lot of openings--whichever black chooses) and the French Defence and Queen's Gambit Accepted as black. Naturally you have to have a line you like vs English, Bird's, London and others.
For fun (speed games) I'll try anything once. I used to vary my play more when I played in the 1970s and 1980s (USCF expert class), but after a long hiatus I started playing again post-retirement and now I don't take things so seriously so I don't care to spend much time keeping up with the latest opening theory.
As black: Tarrasch vs d4&c4. classical Sicilian vs e4. b6 vs b3 & move to something like Tartakower. As white: usually e4 so then I have to have a line vs lots of possibilities--oddly I usually pick an aggressive, critical line as white. I keep my own opening books written down. The white book is thin, has a lot of openings but usually only 1 white line for each. The black book is thick and has only 2 openings & goes both deep and wide for those 2. I am also OK with playing a few others as black but have tried to focus on these two.