Professor Igor,
I don't doubt your mathematics or statistics. I have read a good number of comments and posts whereby you state that 1. e4 is suboptimal and that 1. d4 or 1. c4 are clearly superior to 1. e4. I have also read your comments where 1. ... e5 in response to 1. e4 is suboptimal to the Sicilian.
Yet, SuperGrandmasters seemingly don't put much stock in statistical outcomes. For example, in the first round of today's Sinquefield Cup there were 5 games. 4 of them started out with 1. e4. And in all four of them, the response was 1.... e5! And these are SuperGMs too! And almost all of them deliberately chose to go down "suboptimal" paths?
Don't you think that seems odd? I mean, when they have statistical data and analysis available that shows that their choices are "suboptimal"? Why do you think they choose "suboptimal" openings?
Current status: 7 openings with 60000+ master games. Queen's Gambit and Anglo-Indian: King's Knight are bad for black.