Not for a 500. The Poisoned Pawn Winawer plans are much simpler for White, whereas the Mainline Najdorf plans are much less clear.
I don't see how it's simpler. The plans are just different. In the Winawer Poisoned Pawn you are either defending a pawn up position or trying to split open the kingside.
Main Line Najdorf you are trying to split open the kingside or gambit a pawn for attack.
I would actually compare the Main Line Najdorf very strongly to the Poisoned Pawn Winawer as they are similar in style.
bongcloud