There is a notion that playing some obscure, wild, tricky gambit line against strong opposition is a good way to go. Another notion is to play something very solid and bland, hoping to last as long as possible.
The odds of winning against opposition 600 points stronger than you are are low (estimated at 3%), so what is the best strategy?
In my view, the best strategy is by playing the opening from which you will arrive at middle games for which you best understand the plans and strategies.
Always play what you know best.
(My presumption here is that you are a relatively novice player. But this recommendation would hold for almost any ratings group.)
What's a good opening to use when your playing someone, say 600 points better than you. And I don't want to play for draw either.