No matter what your main line choice is, white has many options on just the 2nd move- the Smith and Wing gambits, c3, Nc3, f4 (and even odd moves like 2) b3 or 2) Na3 - as analyzed in books such as 'Secrets of Opening Surprises' (the SOS series by 'New in Chess')
Thus, when playing the Sicilian as black, as much as you want to play your main line- there will be many times you will face all these 2nd move white options, so that has to be taken into account- if you are wiling to devote the study time to all those sidelines. Perhaps it might also be good - if you are an e4 player, you also need to determine how to play against the Sicilian as white - play against your own lines, or adopt a 2nd move sideline?
I actually am an e4 player and currently play sidelines against the sicilian...rossolimo, moscow, alapin. Also I used to play the closed sicilian as white so getting ready for the sidelines probably wont be a great deal of work of work for me. Im not that familar with the grandprix, wing gambit or the b3 line but I think I prefer to see if I can figure out what to do against those on my own before doing any special study for them.
No matter what your main line choice is, white has many options on just the 2nd move- the Smith and Wing gambits, c3, Nc3, f4 (and even odd moves like 2) b3 or 2) Na3 - as analyzed in books such as 'Secrets of Opening Surprises' (the SOS series by 'New in Chess')
Thus, when playing the Sicilian as black, as much as you want to play your main line- there will be many times you will face all these 2nd move white options, so that has to be taken into account- if you are wiling to devote the study time to all those sidelines. Perhaps it might also be good - if you are an e4 player, you also need to determine how to play against the Sicilian as white - play against your own lines, or adopt a 2nd move sideline?