There is nothing "wrong" with 2.Nc3 if you are happy with a dead equal game.
White's only real shot at an advantage against 1...e5 is the Ruy Lopez or Scotch. Doesn't mean the other moves lose. You just won't see them in very many GM games because most top level players are not happy with an equal position as White. Black they'd be ecstatic to have equality that quickly!
I was looking through my chessbase database and I realized that white played 2.NF3 about 250,000 times compared to 2. NC3 at about 30,000 times (ChessBase Mega DataBase 2013).
I know the ruy lopez is a big contributer to this but I couldn't help but ask myself is 2.NC3 that much worse - I spent two days playing around with variations and reading articles - the following game is the result.