It depends on the situation. Usually, isolated rook pawns are considered a weakness, but there are exceptions.
Isolated rook pawn
Generally a weakness is anything important that your opponent can attack and you can't defend adequately.
It can be the most indefensible pawn or square on the board, but if your opponent can't attack it then no one will bother mentioning it. It may be able to be defended 5 times, but if your opponent can easily attack it 6 times then it's a weak point.
That said, all isolated pawns are potentially weaker than "normal" regardless of whether or not they're rook pawns. What you will want to ponder in an endgame is whether or not capturing it is worth the time it takes to do so. Sometimes it's obvious you want to win a pawn, other times going to the edge of the board isn't worth the tempo. Usually passed pawns get priority. If by capturing a pawn you create a passer for yourself, that's great. And of course when you capture an opponent's passer.
Are isolated rook pawns supposed to be a weakness/target as other isolated pawns?