Statistically, the Flibbenucci variation of the English opening (1.c4 e6 2.Qc2) is the worst. It hardly appears in any databases, and as far as I know, it's only been played once in a master level tournament. And that was a pretty quick loss. This was at the legendary Binford Tournament in 1898. The Bernoullian player Dimitrie Flibbenucci tried it against Horace Finchbaur of Grand Fenwick, with disastrous results:
lols white got killed
I didn't even know about that variation.