It's not chess ability that is relevant here. It appears it can be a psychological barrier to some. Rather some understanding of combinatorics and probability theory is needed.
Most people are incapable of understanding the subtlety that something may be close enough to certain to make it entirely sensible to be certain of it, without it really being so.
For example, if someone said a computer would completely randomly pick a number between 1 and a trillion minus 1 and asked would it be a number you picked (by writing down 12 digits of your choice), you could safely bet your life on it not matching. But while that bet might be reasonable, certainty would be incorrect.
The same is true when the number has 24 digits. Or 48. The probability of a match is so small it is perfectly reasonable to view it as zero. But anyone with adequate understanding can see it is not zero.
The value of 1. e4 e5 2. Ba6 is actually very like that. It is conceivable that multiple flukes (that occur in parts of the analysis tree from this position that we have not looked at) conspire to make the result different to what we are sure of. The probability is low, extremely low (but more than 1 in 10^48, IMO). And this probability does not become zero until thorough analysis has been performed and we have eliminated the possibility of a weird fluke.
Just like for the example of guessing a 24 digit number, I can be absolutely certain that a view that the probability of being right is zero is incorrect. It's actually a small positive number, not zero.
[On an aside, it is fair to say that all scientific knowledge falls into this category of not quite certain. This is a consequence of the inductive way it is derived. With logical reasoning, it is in principle possible to reach certain conclusions but a pedant might say this relies on a belief that no-one has made a mistake. I can't argue with this, but I can ignore it when I consider the conceptual difference!]
All of us commenting here are admittedly inferior judges of what the best moves, systems, plans, strategies, openings, whatever, might be in chess. We have all proved this by not winning every game we have played and cruising to the world championship. There are many, many players far superior to us.
And all of those superior players are demonstrably inferior to the best computer programs in existence today. And these programs are admittedly imperfect; witness the fact that today's programs easily outperform those of 10 years ago, and no one doubts that today's best programs will be outclassed dinosaurs 10 years from now.
The problem with the computer analysis of chess is the fact that the criteria used to evaluate positions however many moves ahead are based on human concepts of good and bad features. The precise values of different features in different positions continues to advance but is not yet foolproof.
As a result, any method of trimming the amount of analysis necessary to solve chess is guaranteed to contain flaws and lead to somewhat inaccurate conclusions. The only 100% reliable solution is brute force calculation of all possible lines of play. The many explanations here and in similar forums as to the impossible immensity of this task convinces me that a quick solution is EXTREMELY unlikely, but saying that it can NEVER be done flies in the face of the history of human ingenuity and unforeseen revolutionary technological breakthroughs.
I'm old enough that I doubt I will ever see chess solved but I do have faith that someday it will happen.