The doubled c pawns plus the isolated a pawn is the biggest clue. My first thought was a sicilian because white has what looks like a maroczy, but then I have to wonder where white's d pawn went and how black has not only his e pawn but two c pawns.
So it's probably a position out of a Steinitz defense with Bxc6 or exchange Spanish with ...bxc6 (which are similar and either could be responsible for this structure). Or something closely related like the delayed /deferred / modern Steinitz in the Spanish.
I was also thinking of the Scotch where black plays Nxc6 because IIRC one or both players usually castle queenside in that (?) but then black wouldn't have an e pawn.
It's conventional wisdom that the opening that players choose to play is one of the most important factors on how the rest of the game will turn out. That being the case, I've sometimes wondered if a chess expert could look at a board in an advanced state and be able to recognise what the opening was. It seems like that should be the case, at least in theory. So here's an example. It's a game between high level players. I wont give any more details away. Can anyone guess what the opening was? Please don't spoil it if you recognise the actual game.