My strongest opening is the Ruy Lopez Exchange (I haven't lost with it in a USCF game yet)
I also play a heck of an alapin variation of the Sicilian defense.
For black, I'm a fan of the classical defense for QGD. I also use the Tarrasch from time to time.
Colle-Zukertort 1.d4-2.Nf3-3.e3-4.Bd3-5.Nbd2-6.b3-7.Bb2-8.Ne5-9.f4-10.g4 + attack the k-side.
I like all o fthe interesting openings that put you in a different position. If my opponent doesn`t know how to play, I have a good chance to make something up. Italian and Spanish isn`t bad, though
I personally like playing d4 because i know the positions and they are not as dangerous. I love playing agianst e4 though slaughting them with a sicilain is so enjoyable ;)