I doubt it. If chess is eventually "solved", even then there will be starting moves that are worse than others. I'm fairly sure a3 would be among those XD
Edit: Oh, now I see you're point. Unless a move like a3 randomly affected a "perfect" game 30 moves later or something, it really wouldn't matter what move white played. That's really cool.
Suppos, for the sake of argument scientists make a breakthrough in quantum computers and we had computers powerful enough to store a 32 piece tablebase and play "perfect chess". We would probably discover that the all knowing computer regards 1 a3 as just as good as 1 e4 or 1 d4 if, in fact, all those moves lead to a draw with correct play. Perhaps even g4 and f3 are no worse. A game between two perfect players might begin 1 a3, h5 2. Nh6, c6 and it is just as good as Rut Lopez assuming that the draw is maintained.