How to respond to 1. e4 c5 2. Bc4

what if your reply is not sicilian defense but e5 as black then what would a good reply to bishop to c4 be?

what?

For what it's worth in master games according chess.com's Opening Explorer, after 1 e4 c5 2 Bc4 over 90% of games had these two Black moves:

2...e6 results in 21% wins for White, 15% draws, and 64% wins for Black.

2...Nc6 results in 24% wins for White, 16% draws, and 62% wins for Black.

Of course, the question becomes: how does Black gain such a big advantage?

I honestly don't know.  After 2...e6 the most common lines are to develop all the N's, usually in the order 3 Nc3 Nc6 4 Nf3 Nf6, in a sort of Four Knights Game and 2...Nc6 with a later ...e6 typically transposes into the same position where White only wins 15% of the time, 20% draws, 65% Black wins.

There are no alternative variations after those two Black 2nd moves -in other words moving other pieces than N's, where White wins anywhere near as much as Black.

In the one game that went as one variation explored in this thread, Black won after 1 e4 c5 2 Bc4 Nc6 3 Qf3 Nf6.

I don't know why all this Black success is so - I haven't explored it to any depth - my best guess is that the White KB is not good a c4 for some reason, but if I ever start playing the Sicilian as Black and run into this situation, I'm developing my N's.