I think your question is too broad. The real question is what sub lines are best for White after ...c5. Unfortunatly I don't see an easy answer, often chess openings have a herd mentality. It only takes a few top players winning with a particular sub-line to start the stampede. For the last 2 years as I have seen in USCF's Chess Life magazine the hottest line in the Sicilian is the Taimanov. If you research the Sicilian you will find the Dragon, Scheveningen & Najdorf all had their day in the sun.
I take the law of large numbers approach. By entering every game I play into a database over time trends appear. Personally I find here at C.com & one day USCF tournaments I manage to make. The Bowlder Attack & the Alapin (c3) are the most common responces. So as a Sicilian player I am forced to spend massive amounts of time trying to perfect my responces up to the 15th move. It really doesn't matter what the best line is for a particular opening if you never see it in real life.
You may want to consider playing many many many games on line at different chess web sites that allow thematic games. Save them to your database along with any other games you play OTB after they have been cruched by the computer. There is no way a trend won't develop after 50 games a real good one at 100 games.
Is it the main line or side line for player with rating 1200+ -2000 ..Thanks the better games and suggestions the more the power .