You are over 2300 rapid, so I'm a bit surprised that you are puzzled on my 6 by a mainline opening. Keep in mind that I'm a d4 player (but I know some Sicilian theory as my chess coach plays the Najdorf), but you should probably specify which 6th move white is playing. I assume you mean 6. Bg5 (the old Russian mainline) when 6...Nbd7 and 6...e6 are the top two moves the engine gives.
6. Be3 English Attack (or the related 6. f3) are what I typically play in off-hand games, but the top moves for black give more options.
Anyhow, back to the 6. Bg5 continuation, I would think ...e6 is more common for the simple fact that black may not be ready to commit the knight to d7 or c6, whereas committing the pawn to e6 is less serious as players wanting to play ...e5 in one move would just do so. I wouldn't be choosing your opening repertoire choice on a smidge of how often people play worse from it because better players are less likely to play worse. In this case, both moves are solid, so I would experiment with both and see which you like more.
I also see you are a chess.com premium member, so maybe you can use the Opening Explorer to investigate further (if you have a platinum or diamond membership), or you could use the many lessons (if you have diamond membership) to search up this opening and see what shows up.
There's also YouTube and surprisingly even Wikipedia has a good entry for some mainline chess openings. They may not be able to answer nuances, but they may at least point you in the right direction.
Nbd7 is rarer and scores better. But I'm not sure I understand the plans or where I can learn it. Does anyone have any ideas?