It depends on your preferences and preparation. All of the major defenses work well.
BEST DEFENCE

Best depends what sort of positions you like.
Generalisations, but Sicilian tends to be more attacking, Caro Kann is a bit slower/more solid, then there's the French, Pirc, Scandinavian etc which are all good openings.

Thanks for the feedback. I will study the Sicillian as presently I favour the Pirc defence. I find this defence seems to slow more players down on their clocks i.e. this defense is more unusual. Comments?

1. ...e6 because it can lead to French , Sicilian , and Benoni at some lines with 2.d4 c5 3.d5 exd5 4.exd5 d6

The Sicilian Najdorf is the absolute best play in chess, but the problem is everyone seems to know it so you'd need to spend countless time learning the theory.
What is the most favourable defence against e2-e4 for black, excluding e7-e5? You can quote defence type name & I will reserch it on my PC. Thanks