What the hell is the East Indian? Based on the rest of your comment, guessing it is one of the unmentioned Nf6/e6 lines, like the Bogo-Indian, Queen's Indian, etc.
Basically it amounts to what you want to deal with.
3.Nc3 allows the Nimzo-Indian, to which White has numerous options, but it also allows you to play the strongest line against the Modern Benoni, the Flick Knife Attack.
By playing 3.Nf3, you need to know Bogo-Indian theory, Queen's Indian theory (3...b6, which is no good after 3.Nc3 due to 4.e4, but is fine after 3.Nf3), and QGD lines where White commits to Nf3 (via 3...d5), and also the Benoni, 3...c5, which many play this way. They play Nimzo'-Indian if 3.Nc3 and Modern Benoni if 3.Nf3 or 3.g3.
With 3.g3, you avoid the Queen's Indian, but still have the Bogo-Catalan, The Catalan itself with 3...d5, and the Fianchetto Benoni with 3...c5
That is the thing about 1.d4, 1.c4, and 1.Nf3. Which lines do you want to deal with? Some players don't open d4, but are willing to transpose to many QP openings. Some play 1.Nf3 or 1.c4 and avoid QP openings completely.
Open 1.c4 and you have to deal with 1...c5, 1...e5, and then be willing to either play the Reti (1.c4 e6 2.Nf3 d5 3.b3 or 3.g3) or else go into a QP opening, like 1.c4 e6 2.Nc3 d5 3.d4 or 3.cxd5 exd5 4.d4)
Open 1.Nf3 and you avoid 1.c4 e5, but now have 1.Nf3 d5 and if 2.c4, deal with Reti lines that the English doesn't allow like 2...d4 or 2...dxc4.
It's a case of pick your poison and nobody can make the choice for you.
For me, I play 2 openings as White in slow time controls. 1.b4 and 1.c4.
When I play 1.c4, I of course allow the 1...e5 and 1...c5 English. Against 1...e6 or 1...c6 followed by ...d5, I allow the QGD and Slav and play d4. I will transpose to the Kings Indian (1.c4 Nf6 2.Nf3 g6 3.Nc3 Bg7 4.e4 - NOT 4.d4, which would allow the Grunfeld - 4...d6 5.d4), but NOT the Grunfeld or Nimzo-Indian, and execute the Anti-Grunfeld (1.c4 Nf6 2.Nc3 d5 3.cxd5 Nxd5 4.Nf3 g6 5.e4 Nxc3 6.dxc3) and Anti-Nimzo/Mikenas-Flohr (1.c4 Nf6 2.Nc3 e6 3.e4).
So pick your poison!
As of recent, I have decided to switch to 1. d4, along with in general changing my repertoire.
To other 1. d4 players, I have a question: How do you play against the east indian?
I am thinking of 3 things against it, being 3. Nc3 (allowing the nimzo), 3. Nf3 (blocking it), or 3. g3 (the catalan).
I just want to hear some thoughts, as I dont know what to do.