Obviously there are strong GMs who played, play and will play 1) e4
Otherwise IMO 1) e4 e5 should be annoying to play at high levels because whether it's the Petrov Defense (1.e4 e5 2. Nf3 Nf6), the Spanish (1.e4 e5 2.Nf3 Nc6 3. Bb5), the Italian (1.e4 e5 2.Nf3 Nc6 3.Bc4), the Scottish (1.e4 e5 2.Nf3 Nc6 3.d4) I have the impression there is no real advantage for White and that it should be harder not to draw than to win.
E4 is played at high level. It is the most popular move on master level.
WHAT E4 OPENINGS SHOULD YOU PLAY:
Vienna System
Italian Game
Evans Gambit
Fried Liver Attack
No
Yes
Maybe?
No
And you forgot the Ruy Lopez.