At what point should you start to play mainlines.
I think there's no hard rule here, but if you're ambitious, the sooner the better
Usually, beginners don't start right away with mainlines because they're a bit complex to handle, but working with mainlines can only help you develop your chess skills.
At what point should you start to play mainlines. I always played mainlines as Black, but had a narrow repertoire. My White repertoire consisted of sidelines which initially served me well. I then reached a point where the stronger players were equalizing without effort when I was White. I agree that you shouldn't expect your openings to win games for you, but I think you need to pose enough opening problems to wear your opponent down some, and at least be able to play for a win even if he replies correctly.