Launch Game Explorer by ...
LEARN -> Openings -Game Explorer.
Make a move for white, say h4.
You'll be told it's the A00: Kadas Opening. A list of related openings are shown.
Database will be set to Master Games by default.
It will show you 13 responses by black, indicate the number of games in the database for each of these responses, and show you the proportions in each set of games where white won, black won and where it was a draw.
Now make your move as black, c5 say.
Game Explorer will tell you that the database contains games with 3 next moves by white.
http://www.chess.com/forum/view/general/a-tally-of-database-users--non-users?quote_id=1565471&page=31 (post 612)
Several people have written sound advice on how to use (and how NOT to use) Game Explorer. It seems a good idea to bring that advice together into a central reference point.