I have the exact same issue 
Did you find a solution?
How to Save settings in Deep Fritz 14
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Whenever i restart the Deep Fritz 14 i Have To redo the settings
For example everytime i Have to
1.)check Long Game settings
2.)change the CPU from 1 to 8
3.)In Engine Parameters i Have to Check ownBook, Best Book Moove
Please tell me the solution that automatically Activate the above 3 setting every time i restart the PC or restart the software I Dont need to redo the settings