Well, simple answer is that it is too early to tell. So also is a newcomer to the top chess world.
I would be tremendously delighted to eat my words and see Wesley So come back and win the Candidates after starting with 2 losses. That would be such a great inspiring story. If Wesley even got back to 50% and/or finished in the top 4 I would be very surprised.
I watched Wesley's Immortal Game against the Legend Garry Kasparov in a rapid game and I was in stunned awe. Wesley is a great player. To make top 10 or top 20 in the world without a coach is practically unheard of. That's how great Wesley's natural talent is.
And truly, Wesley is not a newcomer to the elite circuit of 2750 chess. He knows his colleagues, and how they all have seconds. He needs to recognize that he is a significant competitive disadvantage without a Second.
Round 2 of the 2018 Candidates Tournament concluded and Wesley So is in sole last place with 2 consecutive losses. He suffered horrible attacking losses to Fabiano Caruana and Alexander Grischuk.
In reading various reports Wesley is the only Candidate who does not have a Second, a professional chess player or coach to assist him with opening preparation and all the other various nice things that a Second provides. Every other player has a Second except Wesley! Now Wesley was working with a coach, a GM Tukmakov who's a really excellent trainer. But that was discontinued sometime in 2017.
Now all that Wesley uses is a computer engine for his preparation. With two consecutive losses the pundits are saying that Wesley is done. Kaput. Out of it. They didn't think his chances were very good going into the tournament, but with two consecutive losses, and the psychology that goes with starting 0-2 in a 14 round tournament with the best players in the world, well, it's over for Wesley.
What does this tell me? For all the factual claims that computers are better than humans at chess, the best chess players still need other human chess players (even if they are worse players than you) to help you compete at the highest levels!! A computer is NOT enough.
People need people. Tiger Woods has had many coaches. Rocky Balboa had Mickey and Apollo has trainers. Bobby Fischer had William Lombardy. Magnus has a team of seconds.
For as individual a mano-a-mano intellectual gladiator combat sport that chess is, Wesley (and any other player) just cannot lone wolf it with a computer laptop and an engine, and expect to win. Got to, got to, got to have someone else to talk things over. Sterile computer evaluations can only go so far. Emmanuel Lasker and playing the person, as much as the board, is really manifesting itself as a sensible approach versus Chess.com's CAPS approach.
P.S. As a possibly related aside, I have read a bit about Wesley's adoptive parents/mother and what not. Sounds complicated. IMHO, I think Wesley is better served with a Both/And approach. Both his adoptive mother And a coach/second. Doesn't have to be an Either/Or situation. But must have a Coach/Second.