Resignation is always an option.
Chess.com

Interesting question - I'm not sure white could resign in that position ... it could be a draw by not enough material for black, but I'm not sure about white losing.

Saw a guy resign in a won position once, only 2400 but it was still painful to see. He thought he was lost but missed a winning combination.

I've confirmed it - chess.com does not apply the insufficient material rule if you press the resign button:

Why on earth would material on the board have any effect on the option to resign?
Such an option would be equivalent to throwing the game, so I was wondering if it would be forced into a drawn result instead.
Can GM Resign if they only have 2 pawns and 1 king?