opening lines


Neither one.
The main line of an opening is the line that has been played most often IN RECENT GRANDMASTER TOURNAMENTS.
This probably will NOT be the one listed as most often played in chess.com's explorer, because (a) it's chess.com, (b) that database includes mostly games between low-rated players, and (c) it includes games from all periods, not just recent Grandmaster tournament practise.
The definition of Main Line changes every few years, as new ideas are un-earthed.