e5 (with Nf3 and Be2) is probably best and most played. Nc3 is respectable to and probably slightly less played.
exd5 is probably worst of the 3 even the panov that has the reputation of being strong is not very dangerous against a prepared black player
1 e4 c6
2 d4 d5
3: What's the best move for white? e5? exd5? Nc3?
When I say the best I mean most played between GMs.