I'd say Nf3 with the reti
Closed Games

There are several plans in the QGD. One is exchanging pawns(cxd5 exd5) and then playing Rb1 and b4-b5. Then pick a weakness in black's camp(usually a pawn on c6, but not always) and bear down on it. Another plan is to generate pressure on black's position with Nc3, Bg5 to pin Nf6, Nf3-e5, Qc2, Bd3, Rac1, Rfd1, and in general make central breaks with c5 or e5 hard to get.
I am usually a e4 player but recently I've thought about diversifying my openings. I was wondering, if I should want to learn a closed system, would d4, c4 or Nf3 be best? d4 seems more complicated, but it also seems most rewarding. The problems are that I do not really understand the plans of the QGD, what exactly does white do?