Unless you are Kramnik then no....black suffers from a somewhat serious space disadvantage, and you pretty much have to understand the defense entirely. Kramnik is an automatic draw with the berlin. I remember Kramnik only using 20 minutes or so for the first 22 moves in his game against grischuk at the candidates tournament....grischuk used over an hour and a half. Very deep opening prep.
Besides, more players these days are playing the d3 stuff as white not allowing Nxe4 and the berlin, and getting more interesting play.....it gets similiar to the italian game actually, very static positions.
What is the latest Berlin theory?
Ok, after:
So can white find an advantage? Or are the days of 1. e4 over?