I would say a computer will always try to make the technically best move. A human player, aware of his huge handicap, would try to set up a lot of traps and hope for you to blunder. So I do think a GM might perform better at this task than an engine.
Still, with a queen handicap, one could probably even beat a Carlsen.
Could I beat a GM with a queen handicap? I tried it against chessmaster 10th edition in a 10 minute game and I won. Is a GM better than a chess engine?