So, it's generally accepted the 1.Nf3 is the best opening move for white and 1. ...f6 is the best response. But, obviously in such an unexplored game, there are bound to be those that attempt something different. I've seen 1.e3 played, with the idea to throw off black by playing 2. Qf3 and putting black on the defensive as early as possible. I think after 1.e3 the best response might be 1. ...d5 with the intent of playing 3. ...Bg4 threatening something like Be2. Anyone want to share in these thoughts?